Functional analysis of polymorphonuclear leukocytes in siblings of glucose-6-phosphate dehydrogenase deficiency.

نویسندگان

  • R Matsuura
  • T Kishi
  • H Okahata
  • M Kobayashi
  • A Tanabe
  • N Sakura
  • K Sawano
  • T Usui
چکیده

Several functions of polymorphonuclear leukocytes (PMNL) were examined in two siblings with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In spite of marked depression of G6PD activity of PMNL, the patients had no susceptibility to bacterial infections. Qualitative nitroblue tetrazolium (NET) reduction was normal in both cases. Quantitative NBT reduction was normal in one case and subnormal in the other. Bactericidal activity also was normal. However, superoxide anion (On release, oxygen (02) consumption and chemiluminescence (CL) response were significantly decreased in both cases. This dysfunction was more marked when glucose was added extracellularly. It is concluded that these tests are more suitable than the NET test for the screening of PMNL G6PD deficiency. It is also considered that there is a large reserve supply of active oxygens necessary for normal bactericidal activity of PMNL. 173

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Molecular Identification of the Most Prevalent Mutations of Glucose-6-Phosphate Dehydrogenase (G6PD) in Fars and Isfahan of Iran

Glucose-6-phosphate dehydrogenase (G6PD) in humans is in X-linked disorder, housekeeping enzyme and vital for the survival of every cell. It catalyses the oxidation of glucose-6-phosphate to 6-phospho Gluconat in the first committed step of the pentose phosphate pathway, which provides cells with pentoses and reducing power in the form of NADPH. NADPH is required to protect the cells against ox...

متن کامل

Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Male Donors in Shiraz, Southern Iran

The overall incidence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Iranian population is estimated around 10%-14.9%. G6PD deficiency is an X-linked disorder and 80% of donors are usually male. At present, donors’ blood is not routinely screened for G6PD deficiency in Iran blood bank where for detecting such enzyme deficiency, reliance is placed on pre-donation data. Thus, the G6PD ...

متن کامل

Possible Association between Glucose-6-Phosphate Dehydrogenase Deficiency and the Development of Preeclampsia

Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency in the world. It's Prevalence inIranis about 12% in male & about 1% in female. The present study did examine the relation between the development of preeclampsia and G6PD deficiency. It was investigated whether or not the risk of preeclampsia in G6PD deficient women is higher than that in normal pregnant women.A t...

متن کامل

Prevalence of Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Jiroft City in Southern Iran

Background and Aims: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a global problem and the most common cause of jaundice in neonates. Hence, this study was conducted to investigate the prevalence of G6PD deficiency in Jiroft city in southern Kerman. Materials and Methods: This descriptive cross-sectional study was carried out from 2016 to 2019. Blood samples were taken from all patie...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Hiroshima journal of medical sciences

دوره 32 2  شماره 

صفحات  -

تاریخ انتشار 1983